Short-term treadmill running in the rat: what kind of stressor is it?

نویسندگان

  • David A Brown
  • Micah S Johnson
  • Casey J Armstrong
  • Joshua M Lynch
  • Nicholas M Caruso
  • Lindsay B Ehlers
  • Monika Fleshner
  • Robert L Spencer
  • Russell L Moore
چکیده

The use of short-term (1-5 days) treadmill running is becoming increasingly common as a model to study physiological adaptations following the exercise. Although the beneficial effects of acute exercise seem clear, a paucity of data exist describing potential markers of stress in response to forced running. We subjected male and female Sprague-Dawley rats to 0, 1, 2, 5, or 10 days of treadmill running. Twenty-four to 32 h after the last bout of exercise animals were killed and examined for training-induced changes in several physiological variables. No effect of skeletal citrate synthase activity was observed in the male animals after any duration, and only at 10 days of running did females show a significant increase in citrate synthase. Myocardial heat shock protein 72 (HSP72) content was higher in male rats than female rats, and exercise led to increased HSP72 in both sexes, although the time course was different between males and females. Animals displayed several markers of systemic stress in response to the treadmill running, and this was done in a sex-dependent manner. Serum corticosterone was significantly elevated in both sexes 24 h after exercise in three of four exercise groups. Corticosterone-binding globulin was higher in females, and decreased after running in female rats. Body and spleen weights decreased in males (but not females) in response to the exercise training, and running did not alter adrenal gland weights in either sex. These data indicate that in response to short-term treadmill running both male and female rats show signs of systemic stress, but that the pattern of changes occurs in a sex-specific manner.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of Physical Activity on Symptoms of Morphine Addiction in Rats, after and before of Lesion of the mPFC Area

  Objective(s): Drug addiction is one of the fastest growing social problems that researchers, for many years, have been trying to find proper strategies for its prevention and treatment. Short-term physical activity is considered as acceptable for the treatment and prevention of addiction. On the other hand, prefrontal cortex is known to be responsible for many of the complex behavi...

متن کامل

The Effects of Exercise on Expression of CYP19 and StAR mRNA in Steroid-Induced Polycystic Ovaries of Female Rats

Objective PCOS is the most frequent female endocrine disorder, affecting 5%-10% of women, is characterized by hyperandrogenism, oligo-/anovulation, and polycystic ovaries. The aim of the present research is to evaluate the expression of steroidogenic acute regulatory protein (StAR) and CYP19 (aromatase) mRNA in the ovary of EV-induced PCOS rat model and the effect of the treadmill and running w...

متن کامل

Effect of treadmill running on pain level of patients with anterior knee pain syndrome

: Anterior knee pain is pain that occurs in the front and center of the knee and has a high prevalence, which is necessary to study the therapeutic effect of different methods on the pain of this disease. the aim of this study was to investigate the effect of treadmill use on pain in patients with anterior knee pain syndrome. : This study was performed on 136 patients with anterior knee pain ...

متن کامل

The effects of moderate treadmill and running wheel exercises on oxidative stress in female rats with steroid-induced polycystic ovaries

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrinological pathologies in women during their reproductive years with ovulatory dysfunction, abdominal obesity, hyperandrogenism and insulin resistance. The aim of the present research was to evaluate the total antioxidant capacity (TAC), total oxidant status (TOS), free testosterone, ovarian morphology and estrous cy...

متن کامل

Age-Related Changes in Doxorubicin-Induced Oxidative Damage: Protective and Pretreatment Effects of Short-Term Aerobic Exercise

ABSTRACT        Background and Objective: Doxorubicin (DOX) is an effective anticancer drug. It has been shown that  a short-term exercise performed prior to DOX-treatment has no effect on cardiotoxicity in young rats. In the present study, old and young rats were evaluated to determine the protective effects of pre-treatment with short-term exercise on D...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Journal of applied physiology

دوره 103 6  شماره 

صفحات  -

تاریخ انتشار 2007